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Evaluation of superoxide dismutase from Helicobacter pylori as a protective vaccine antigen
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Journal Article
Evaluation of superoxide dismutase from Helicobacter pylori as a protective vaccine antigen
2011
Overview
Helicobacter pylori, the major cause of gastric cancer, have mechanisms that allow colonization of the inhospitable gastric mucosa, including enzymes such as superoxide dismutase (SOD) which protect against reactive oxygen species. As SOD is essential for in vivo colonization, we theorized it might constitute a viable vaccine target. H. pylori SOD was expressed in E. coli and a purified recombinant protein used to vaccinate mice, prior to live H. pylori challenge. Partial protective immunity was induced, similar to that commonly observed with other antigens tested previously. This suggests SOD may have utility in a combination vaccine comprising several protective antigens.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Animals
/ Antibodies, Bacterial - blood
/ antigens
/ Antigens, Bacterial - genetics
/ Antigens, Bacterial - immunology
/ Bacteria
/ Bacterial Vaccines - immunology
/ Biological and medical sciences
/ Cloning
/ DNA
/ Enzymes
/ Escherichia coli - immunology
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Helicobacter Infections - immunology
/ Helicobacter Infections - prevention & control
/ Helicobacter pylori - enzymology
/ Helicobacter pylori - immunology
/ immunity
/ Mice
/ Proteins
/ Recombinant Proteins - genetics
/ Recombinant Proteins - immunology
/ Superoxide Dismutase - genetics
/ Superoxide Dismutase - immunology
/ Ulcers
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
