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Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by
Silveria, Mark A.
, Large, Edward E.
, Chapman, Michael S.
, Zane, Grant M.
, Weerakoon, Onellah
in
AAV
/ AAV attachment factor
/ AAV receptor
/ adeno-associated virus
/ Amino acids
/ Animals
/ Binding sites
/ Biotechnology
/ capsid
/ Clinical trials
/ conception
/ Dependoparvovirus
/ Dependovirus - genetics
/ Expression vectors
/ Gene therapy
/ Gene transfer
/ Gene Transfer Techniques
/ Genetic Therapy - methods
/ Genetic Vectors - genetics
/ Genetic Vectors - metabolism
/ Genomes
/ HeLa Cells
/ Humans
/ major genes
/ Mice
/ Plasmids
/ Proteins
/ Receptors, Virus - genetics
/ Review
/ Transduction, Genetic
/ Vectors (Biology)
/ Virus Internalization
/ virus structure
/ Viruses
2021
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Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by
Silveria, Mark A.
, Large, Edward E.
, Chapman, Michael S.
, Zane, Grant M.
, Weerakoon, Onellah
in
AAV
/ AAV attachment factor
/ AAV receptor
/ adeno-associated virus
/ Amino acids
/ Animals
/ Binding sites
/ Biotechnology
/ capsid
/ Clinical trials
/ conception
/ Dependoparvovirus
/ Dependovirus - genetics
/ Expression vectors
/ Gene therapy
/ Gene transfer
/ Gene Transfer Techniques
/ Genetic Therapy - methods
/ Genetic Vectors - genetics
/ Genetic Vectors - metabolism
/ Genomes
/ HeLa Cells
/ Humans
/ major genes
/ Mice
/ Plasmids
/ Proteins
/ Receptors, Virus - genetics
/ Review
/ Transduction, Genetic
/ Vectors (Biology)
/ Virus Internalization
/ virus structure
/ Viruses
2021
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Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by
Silveria, Mark A.
, Large, Edward E.
, Chapman, Michael S.
, Zane, Grant M.
, Weerakoon, Onellah
in
AAV
/ AAV attachment factor
/ AAV receptor
/ adeno-associated virus
/ Amino acids
/ Animals
/ Binding sites
/ Biotechnology
/ capsid
/ Clinical trials
/ conception
/ Dependoparvovirus
/ Dependovirus - genetics
/ Expression vectors
/ Gene therapy
/ Gene transfer
/ Gene Transfer Techniques
/ Genetic Therapy - methods
/ Genetic Vectors - genetics
/ Genetic Vectors - metabolism
/ Genomes
/ HeLa Cells
/ Humans
/ major genes
/ Mice
/ Plasmids
/ Proteins
/ Receptors, Virus - genetics
/ Review
/ Transduction, Genetic
/ Vectors (Biology)
/ Virus Internalization
/ virus structure
/ Viruses
2021
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Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
Journal Article
Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
2021
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Overview
Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of AAV capsid modification strategies. Significant factors influencing rAAV transduction efficiency include neutralizing antibodies, attachment factor interactions and receptor binding. Advances in understanding the molecular interactions during rAAV cell entry combined with improved capsid modulation strategies will help guide the design and engineering of safer and more efficient rAAV gene therapy vectors.
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