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Low discontinuation rate of tirzepatide treatment in Japanese patients with diabetes mellitus; importance of traditional Japanese diet
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Low discontinuation rate of tirzepatide treatment in Japanese patients with diabetes mellitus; importance of traditional Japanese diet
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Journal Article
Low discontinuation rate of tirzepatide treatment in Japanese patients with diabetes mellitus; importance of traditional Japanese diet
2025
Overview
Tirzepatide, a novel dual GIP and GLP-1 receptor agonist, has demonstrated robust efficacy in clinical trials; however, discontinuation rates due to gastrointestinal adverse events have been reported at 6–10% in Western populations. In contrast, our real-world study of 219 Japanese patients revealed a markedly lower discontinuation rate of approximately 1.3%. Dietary questionnaires indicated that patients experienced reduced appetite for high-fat and high-calorie foods while maintaining consumption of low-carbohydrate traditional Japanese foods such as fish and meat, which may have contributed to the low discontinuation rate.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Agonists
/ Appetite
/ Consent
/ Diabetes
/ Diabetes Mellitus, Type 2 - diet therapy
/ Diabetes Mellitus, Type 2 - drug therapy
/ Diet
/ Efficacy
/ Female
/ Fish
/ Food
/ Gastric Inhibitory Polypeptide - adverse effects
/ Gastric Inhibitory Polypeptide - analogs & derivatives
/ Gastric Inhibitory Polypeptide - therapeutic use
/ Health Promotion and Disease Prevention
/ Humans
/ Hypoglycemic Agents - adverse effects
/ Hypoglycemic Agents - therapeutic use
/ Japan
/ Male
/ Meat
/ Medicine
/ Motility
/ Nausea
/ Patients
/ Proteins
/ Vomiting
