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Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling
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Journal Article
Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling
2010
Overview
In a population-based study, emphysema was quantified by computed tomography, pulmonary function was assessed by spirometry, and cardiac volumes and function were measured by magnetic resonance imaging. Both percent emphysema and the severity of airflow obstruction were linearly related to reductions in left ventricular end-diastolic volume, stroke volume, and cardiac output. These effects were more pronounced among smokers.
In a population-based study, emphysema and the severity of airflow obstruction were linearly related to reductions in left ventricular end-diastolic volume, stroke volume, and cardiac output.
Chronic obstructive pulmonary disease (COPD), defined as airflow obstruction that is not fully reversible,
1
is currently the fourth leading cause of death in the United States.
2
COPD overlaps partially with emphysema, which is characterized by the destruction of alveolar walls and the permanent enlargement of air spaces distal to the terminal bronchioles.
1
,
3
Cor pulmonale, which can occur in very severe COPD, is characterized by elevated pulmonary vascular resistance and right heart failure, with associated reductions in left ventricular filling, left ventricular stroke volume, and cardiac output, although left ventricular ejection fraction is generally preserved.
4
–
7
This disorder may occur . . .
Publisher
Massachusetts Medical Society
Subject
/ Airway Obstruction - complications
/ Airway Obstruction - physiopathology
/ Biological and medical sciences
/ Chronic obstructive pulmonary disease
/ Chronic obstructive pulmonary disease, asthma
/ Edema
/ Female
/ Heart
/ Humans
/ Hypoxia
/ Male
/ NMR
/ Pulmonary Emphysema - complications
/ Pulmonary Emphysema - diagnostic imaging
/ Pulmonary Emphysema - physiopathology
/ Smoking
/ Software
/ Stroke
/ Structure-function relationships
/ Thorax
/ Ventricular Dysfunction, Left - etiology
