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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
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Journal Article
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
2012
Overview
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca²⁺ channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the nodal flow. Examination of mutant forms of Pkd2 shows that the ciliary localization of Pkd2 is essential for correct L-R patterning. Whereas Kif3a mutant embryos, which lack all cilia, failed to respond to an artificial flow, restoration of primary cilia in crown cells rescued the response to the flow. Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ calcium
/ cations
/ Channels
/ Cilia
/ Embryo, Mammalian - anatomy & histology
/ Embryo, Mammalian - cytology
/ Embryo, Mammalian - physiology
/ Embryology: invertebrates and vertebrates. Teratology
/ Embryos
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Human
/ humans
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Left-Right Determination Factors - genetics
/ Left-Right Determination Factors - metabolism
/ Mice
/ Mutation
/ Organizers, Embryonic - cytology
/ Organizers, Embryonic - physiology
/ Organogenesis. Fetal development
/ Organogenesis. Physiological fonctions
/ Organs
/ Symmetry
/ TRPP Cation Channels - genetics
