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Discovery and population genomics of structural variation in a songbird genus
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Discovery and population genomics of structural variation in a songbird genus
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Journal Article
Discovery and population genomics of structural variation in a songbird genus
2020
Overview
Structural variation (SV) constitutes an important type of genetic mutations providing the raw material for evolution. Here, we uncover the genome-wide spectrum of intra- and interspecific SV segregating in natural populations of seven songbird species in the genus
Corvus
. Combining short-read (
N
= 127) and long-read re-sequencing (
N
= 31), as well as optical mapping (
N
= 16), we apply both assembly- and read mapping approaches to detect SV and characterize a total of 220,452 insertions, deletions and inversions. We exploit sampling across wide phylogenetic timescales to validate SV genotypes and assess the contribution of SV to evolutionary processes in an avian model of incipient speciation. We reveal an evolutionary young (~530,000 years)
cis
-acting 2.25-kb LTR retrotransposon insertion reducing expression of the
NDP
gene with consequences for premating isolation. Our results attest to the wealth and evolutionary significance of SV segregating in natural populations and highlight the need for reliable SV genotyping.
Structural genomic variation can fuel evolution. Here, authors present genome data from seven
Corvus
species and unearth structural variants that vary between incipient crow species in Europe, with implications for premating isolation involving plumage patterning.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
