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Mitochondrial Fission, Fusion, and Stress
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Journal Article
Mitochondrial Fission, Fusion, and Stress
2012
Overview
Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can facilitate apoptosis during high levels of cellular stress. Disruptions in these processes affect normal development, and they have been implicated in neurodegenerative diseases, such as Parkinson's.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Cell structures and functions
/ Division
/ DNA, Mitochondrial - genetics
/ Dynamics
/ Fission
/ Fundamental and applied biological sciences. Psychology
/ genome
/ Humans
/ Mice
/ Mitochondria and cell respiration
/ Mitochondrial Diseases - metabolism
/ Mitochondrial Proteins - genetics
/ Mitochondrial Proteins - metabolism
/ Molecular and cellular biology
/ Mutation
/ Neurodegenerative Diseases - metabolism
/ Neurons
/ P branes
/ Parkinson Disease - metabolism
/ REVIEW
/ Stresses
