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Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA
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Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA
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Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA
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Journal Article
Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA
2018
Overview
Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression and plant development. Here, we identified 6,510 lncRNAs in
Arabidopsis
under normal or stress conditions. We found that the expression of natural antisense transcripts (NATs) that are transcribed in the opposite direction of protein-coding genes often positively correlates with and is required for the expression of their cognate sense genes. We further characterized
MAS
, a NAT-lncRNA produced from the
MADS AFFECTING FLOWERING4
(
MAF4)
locus.
MAS
is induced by cold and indispensable for the activation of
MAF4
transcription and suppression of precocious flowering.
MAS
activates
MAF4
by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to
MAF4
to enhance histone 3 lysine 4 trimethylation (H3K4me3). Our study greatly extends the repertoire of lncRNAs in
Arabidopsis
and reveals a role for NAT-lncRNAs in regulating gene expression in vernalization response and likely in other biological processes.
Long non-coding RNAs regulate developmental transitions and stress responses in plants. Here Zhao et al. show that a non-coding antisense transcript
MAS
transcribed from the
Arabidopsis MAF4
locus activates H3K4me3 deposition and
MAF4
transcription to suppress precocious flowering.
