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Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

by Kim, Inyong , Brinkmann, Benjamin H. , Worrell, Gregory A. , Balzekas, Irena , Patterson, Edward E. , Leyde, Kent , Mivalt, Filip , Denison, Timothy J. , Gregg, Nicholas M. , Van Gompel, Jamie J. , Sturges, Beverly K. , Crowe, Chelsea , Kremen, Vaclav , Sladky, Vladimir , Nejedly, Petr , Lundstrom, Brian N.

in 631/378/1689/178 / 631/378/3920 / 692/617/375/178 / Animals / Circadian Rhythm / Circadian rhythms / Convulsions & seizures / Deep brain stimulation / Deep Brain Stimulation - methods / Dogs / EEG / Electroencephalography / Epilepsy / Epilepsy - prevention & control / Excitability / Firing rate / Frequency dependence / Human subjects / Humanities and Social Sciences / Humans / multidisciplinary / Pets / Positron emission tomography / Risk / Science / Science (multidisciplinary) / Seizures / Seizures - prevention & control / Thalamus / Thalamus - physiology

2021

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Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

2021

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2021

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Journal Article

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

Kim, Inyong,

Brinkmann, Benjamin H.,

Worrell, Gregory A.,

Balzekas, Irena,

Patterson, Edward E.,

Leyde, Kent,

Mivalt, Filip,

Denison, Timothy J.,

Gregg, Nicholas M.,

Van Gompel, Jamie J.,

Sturges, Beverly K.,

Crowe, Chelsea,

Kremen, Vaclav,

Sladky, Vladimir,

Nejedly, Petr,

Lundstrom, Brian N.

2021

Overview

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ Animals

/ Convulsions & seizures