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Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
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Journal Article
Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
2018
Overview
The vagus nerve is the primary means of neural communication between the gastrointestinal (GI) tract and the brain. Vagally mediated GI signals activate the hippocampus (HPC), a brain region classically linked with memory function. However, the endogenous relevance of GI-derived vagal HPC communication is unknown. Here we utilize a saporin (SAP)-based lesioning procedure to reveal that selective GI vagal sensory/afferent ablation in rats impairs HPC-dependent episodic and spatial memory, effects associated with reduced HPC neurotrophic and neurogenesis markers. To determine the neural pathways connecting the gut to the HPC, we utilize monosynaptic and multisynaptic virus-based tracing methods to identify the medial septum as a relay connecting the medial nucleus tractus solitarius (where GI vagal afferents synapse) to dorsal HPC glutamatergic neurons. We conclude that endogenous GI-derived vagal sensory signaling promotes HPC-dependent memory function via a multi-order brainstem–septal pathway, thereby identifying a previously unknown role for the gut–brain axis in memory control.
Feeding-relevant vagal signaling occurs between the gastrointestinal tract and the brain, but it is unclear if this pathway influences cognitive processes. This study shows that endogenous gastrointestinal derived vagal sensory signaling promotes hippocampal-dependent memory function via a multi-order brainstem–septal pathway.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/378
/ 64/86
/ 82/29
/ 82/51
/ 82/80
/ 96/63
/ Animals
/ Brain
/ Brain-derived neurotrophic factor
/ Cerebral Cortex - physiology
/ Gastrointestinal Tract - innervation
/ Humanities and Social Sciences
/ Male
/ Memory
/ Neural Pathways - physiology
/ Saporin
/ Science
/ Sensory Receptor Cells - physiology
/ Septum
/ Synapses
/ Viruses
