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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
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Journal Article
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
2020
Overview
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S
G614
) with the original (S
D614
). We report here pseudoviruses carrying S
G614
enter ACE2-expressing cells more efficiently than those with S
D614
. This increased entry correlates with less S1-domain shedding and higher S-protein incorporation into the virion. Similar results are obtained with virus-like particles produced with SARS-CoV-2 M, N, E, and S proteins. However, D614G does not alter S-protein binding to ACE2 or neutralization sensitivity of pseudoviruses. Thus, D614G may increase infectivity by assembling more functional S protein into the virion.
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/109
/ 13/31
/ ACE2
/ Angiotensin-converting enzyme 2
/ Angiotensin-Converting Enzyme 2 - metabolism
/ COVID-19
/ Humanities and Social Sciences
/ Humans
/ Mutation
/ Proteins
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Spike Glycoprotein, Coronavirus - genetics
/ Spike Glycoprotein, Coronavirus - metabolism
/ Spikes
/ Virions
