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Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe
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Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe
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Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe
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Journal Article
Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe
2019
Overview
Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of
Drosophila
. Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABA
B
- and GABA
A
receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant- and repellent-responsive circuits. This inhibitory interaction biases the behavioral output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information.
Fruit flies need to appropriately respond to mixtures of attractive and repellent odors in their natural environment. Here, the authors propose that lateral inhibition between glomeruli activated by attractants or repulsive odors mediates the appropriate response.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/35
/ 14/69
/ 38/89
/ 64/24
/ 82/51
/ Animals
/ Animals, Genetically Modified
/ Arthropod Antennae - innervation
/ Behavior, Animal - physiology
/ Channels
/ Drosophila melanogaster - physiology
/ Excitatory Postsynaptic Potentials - physiology
/ Female
/ GABAergic Neurons - physiology
/ Humanities and Social Sciences
/ Inhibitory Postsynaptic Potentials - physiology
/ Insects
/ Odor
/ Odorants
/ Odors
/ Olfactory Pathways - physiology
/ Olfactory Perception - physiology
/ Olfactory Receptor Neurons - physiology
/ Receptors, Odorant - genetics
/ Receptors, Odorant - physiology
/ Science
