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$Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae$

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

by Hites, Maya , Leshkasheli, Lika , Balarjishvili, Nana , de Boer, Mark , Askilashvili, Lia , Nibbering, Peter , Chanishvili, Nina , Kutateladze, Mzia , Merabishvili, Maya , Jayankura, Marc , Lood, Cédric , Wubbolts, Julia , Wagemans, Jeroen , Lavigne, Rob , Pirnay, Jean-Paul , Eskenazi, Anaïs , Kvachadze, Leila , van Noort, Vera

in 631/326/107 / 631/326/1321 / 692/699/255/1318 / 692/700/565 / Adult / Anti-Bacterial Agents - therapeutic use / Antibiotics / Azabicyclo Compounds - pharmacology / Azabicyclo Compounds - therapeutic use / Bacteriophages - genetics / Bacteriophages - ultrastructure / Biofilms / Biofilms - drug effects / Ceftazidime / Ceftazidime - pharmacology / Ceftazidime - therapeutic use / Colistin / CpG Islands - genetics / Drug Combinations / Drug Resistance, Microbial - drug effects / Drug Resistance, Microbial - genetics / Drug Resistance, Multiple, Bacterial / Fractures, Bone - complications / Fractures, Bone - diagnostic imaging / Fractures, Bone - microbiology / Genome, Viral / Humanities and Social Sciences / Humans / Infections / Klebsiella / Klebsiella Infections - complications / Klebsiella Infections - diagnostic imaging / Klebsiella Infections - microbiology / Klebsiella Infections - therapy / Klebsiella pneumoniae / Klebsiella pneumoniae - drug effects / Klebsiella pneumoniae - genetics / Klebsiella pneumoniae - isolation & purification / Klebsiella pneumoniae - physiology / Meropenem / Microbial Sensitivity Tests / multidisciplinary / Patients / Phage Therapy / Phages / Polymorphism, Single Nucleotide - genetics / Proteomics / Replicon - genetics / Science / Science (multidisciplinary) / Therapy

2022

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Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

2022

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$Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae$

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

2022

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$Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae$

Journal Article

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Hites, Maya,

Leshkasheli, Lika,

Balarjishvili, Nana,

de Boer, Mark,

Askilashvili, Lia,

Nibbering, Peter,

Chanishvili, Nina,

Kutateladze, Mzia,

Merabishvili, Maya,

Jayankura, Marc,

Lood, Cédric,

Wubbolts, Julia,

Wagemans, Jeroen,

Lavigne, Rob,

Pirnay, Jean-Paul,

Eskenazi, Anaïs,

Kvachadze, Leila,

van Noort, Vera

2022

Overview

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions. In this case study of a patient with fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term antibiotic therapy, the authors use a combination therapy of pre-adapted bacteriophage and antibiotics resulting in clinical, microbiological and radiological improvement.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ Adult

/ Anti-Bacterial Agents - therapeutic use

/ Antibiotics