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DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
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DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
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DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
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Journal Article
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
2017
Overview
Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in the injured DRG neurons via the activation of the transcription factor octamer transcription factor 1. Blocking this increase prevents nerve injury-induced methylation of the voltage-dependent potassium (Kv) channel subunit
Kcna2
promoter region and rescues
Kcna2
expression in the injured DRG and attenuates neuropathic pain. Conversely, in the absence of nerve injury, mimicking this increase reduces the
Kcna2
promoter activity, diminishes
Kcna2
expression, decreases Kv current, increases excitability in DRG neurons and leads to spinal cord central sensitization and neuropathic pain symptoms. These findings suggest that DNMT3a may contribute to neuropathic pain by repressing
Kcna2
expression in the DRG.
Transcriptional changes occur in the dorsal root ganglion in response to nerve injury and may contribute to neuropathic pain. Here the authors show that the DNA methyltransferase DNMT3a is upregulated in rodents following nerve injury, and may contribute to pain-like behaviour by decreasing expression of the voltage-gated potassium channel Kv1.2.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/51
/ 38
/ 38/22
/ 38/77
/ 82
/ 82/1
/ 82/29
/ 82/51
/ 82/80
/ 9/74
/ Animals
/ Central Nervous System Sensitization - genetics
/ DNA
/ DNA (Cytosine-5-)-Methyltransferases - genetics
/ Humanities and Social Sciences
/ Kv1.2 Potassium Channel - genetics
/ Kv1.2 Potassium Channel - metabolism
/ Ligation
/ Male
/ Mimicry
/ Neurons
/ Neurons, Afferent - metabolism
/ Octamer Transcription Factor-1 - genetics
/ Pain
/ Peripheral Nerve Injuries - genetics
/ Potassium channels (voltage-gated)
/ Proteins
/ Rats
/ Science
/ Surgery
