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Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization
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Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization
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Journal Article
Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization
2017
Overview
The Lyme disease agent,
Borrelia burgdorferi
, colonizes the gut of the tick
Ixodes scapularis
, which transmits the pathogen to vertebrate hosts including humans. Here we show that
B
.
burgdorferi
colonization increases the expression of several tick gut genes including
pixr
, encoding a secreted gut protein with a Reeler domain. RNA interference-mediated silencing of
pixr
, or immunity against PIXR in mice, impairs the ability of
B
.
burgdorferi
to colonize the tick gut. PIXR inhibits bacterial biofilm formation in vitro and in vivo. Abrogation of PIXR function in vivo results in alterations in the gut microbiome, metabolome and immune responses. These alterations influence the spirochete entering the tick gut in multiple ways. PIXR abrogation also impairs larval molting, indicative of its role in tick biology. This study highlights the role of the tick gut in actively managing its microbiome, and how this impacts
B
.
burgdorferi
colonization of its arthropod vector.
Borrelia burgdorferi
, the causative agent of Lyme disease, is transmitted by the tick
Ixodes scapularis
. Here, the authors show that a tick secreted protein (PIXR) modulates the tick gut microbiota and facilitates
B
.
burgdorferi
colonization.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
