Asset Details
Do you wish to reserve the book?
Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
Do you wish to request the book?
Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
2021
Overview
Germ cells are physically coupled to somatic support cells of the gonad during differentiation, but this coupling must be disrupted when they are mature, freeing them to participate in fertilization. In mammalian females, coupling occurs via specialized filopodia that project from the ovarian follicular granulosa cells to the oocyte. Here, we show that signaling through the epidermal growth factor receptor (EGFR) in the granulosa, which becomes activated at ovulation, uncouples the germ and somatic cells by triggering a massive and temporally synchronized retraction of the filopodia. Although EGFR signaling triggers meiotic maturation of the oocyte, filopodial retraction is independent of the germ cell state, being regulated solely within the somatic compartment, where it requires ERK-dependent calpain-mediated loss of filopodia-oocyte adhesion followed by Arp2/3-mediated filopodial shortening. By uncovering the mechanism regulating germ-soma uncoupling at ovulation, our results open a path to improving oocyte quality in human and animal reproduction.
Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filopodia.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/95
/ 14/1
/ 14/19
/ 14/63
/ 64
/ 64/60
/ 82/51
/ 96
/ Actin-Related Protein 2-3 Complex - metabolism
/ Adhesion
/ Animals
/ Calpain
/ Cell Communication - physiology
/ Coupling
/ Epidermal growth factor receptors
/ Female
/ Granulosa Cells - metabolism
/ Humanities and Social Sciences
/ Meiosis
/ Mice
/ Oocytes
/ Science
/ Signal Transduction - physiology
/ Swine
