Asset Details
Do you wish to reserve the book?
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Do you wish to request the book?
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
2021
Overview
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid, 5-oxoproline, and β-hydroxyisobutyric acid as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters. 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid induce a brown adipocyte-specific phenotype in white adipocytes and mitochondrial oxidative energy metabolism in skeletal myocytes both in vitro and in vivo. 3-methyl-2-oxovaleric acid and 5-oxoproline signal through cAMP-PKA-p38 MAPK and β-hydroxyisobutyric acid via mTOR. In humans, plasma and adipose tissue 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid concentrations correlate with markers of adipose browning and inversely associate with body mass index. These metabolites reduce adiposity, increase energy expenditure and improve glucose and insulin homeostasis in mouse models of obesity and diabetes. Our findings identify beige adipose-brown adipose-muscle physiological metabokine crosstalk.
Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti-obesity effects in mouse models of obesity and diabetes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 38/1
/ 38/39
/ 38/43
/ 38/77
/ 38/89
/ 38/90
/ 38/91
/ 59/78
/ 64/60
/ 82/51
/ 82/58
/ 96/106
/ 96/63
/ Acids
/ Adipocytes, Brown - metabolism
/ Adipocytes, White - metabolism
/ Adipose Tissue, Beige - cytology
/ Adipose Tissue, Beige - metabolism
/ Adipose Tissue, Brown - cytology
/ Adipose Tissue, Brown - metabolism
/ Animals
/ Browning
/ Diabetes
/ Energy Metabolism - genetics
/ Gas Chromatography-Mass Spectrometry
/ Gene Expression Profiling - methods
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Male
/ Mice
/ Muscles
/ Myocytes
/ Obesity
/ Organs
/ Science
