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Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats

by Sinopoli, Jacob , Grenier, Jennifer K. , Laird, Diana J. , Goben, Meagan , Wagner, Kate , McGrath, Ashley , Brieño-Enríquez, Miguel Angel , Walsh, Patrick T. , Lopa, Samia H. , Cohen, Paula E. , Wilson, Michael D. , Place, Ned J. , Faykoo-Martinez, Mariela , Prado, Alexandra M. , Holmes, Melissa M.

in 13 / 13/1 / 13/106 / 13/2 / 13/51 / 14 / 14/63 / 38 / 38/39 / 38/88 / 45 / 45/88 / 45/90 / 45/91 / 49 / 631/136 / 631/532 / 631/80 / Animals / Cell Differentiation / Cell proliferation / Female / Females / Fertility / Germ Cells / Humanities and Social Sciences / Life span / Mitosis / Mole Rats / multidisciplinary / Oct-4 protein / Oogenesis / Ovarian Reserve / Ovaries / Ovary / Pluripotency / Science / Science (multidisciplinary) / Synchronization

2023

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2023

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2023

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Journal Article

Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats

Sinopoli, Jacob,

Grenier, Jennifer K.,

Laird, Diana J.,

Goben, Meagan,

Wagner, Kate,

McGrath, Ashley,

Brieño-Enríquez, Miguel Angel,

Walsh, Patrick T.,

Lopa, Samia H.,

Cohen, Paula E.,

Wilson, Michael D.,

Place, Ned J.,

Faykoo-Martinez, Mariela,

Prado, Alexandra M.,

Holmes, Melissa M.

2023

Overview

In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs postnatally. Germ cell numbers increase significantly in NMRs between postnatal days 5 (P5) and P8, and germs cells positive for proliferation markers (Ki-67, pHH3) are present at least until P90. Using pluripotency markers (SOX2 and OCT4) and the primordial germ cell (PGC) marker BLIMP1, we show that PGCs persist up to P90 alongside germ cells in all stages of female differentiation and undergo mitosis both in vivo and in vitro. We identified VASA+ SOX2+ cells at 6 months and at 3-years in subordinate and reproductively activated females. Reproductive activation was associated with proliferation of VASA+ SOX2+ cells. Collectively, our results suggest that highly desynchronized germ cell development and the maintenance of a small population of PGCs that can expand upon reproductive activation are unique strategies that could help to maintain the NMR’s ovarian reserve for its 30-year reproductive lifespan. Female naked mole rats are long lived and show little or no decline in fertility over their lifespan. Here Brieño-Enríquez et al ., demonstrate that naked mole-rats establish an exceptionally large ovarian reserve and undergo postnatal oogenesis.

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Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

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/ 13/1

/ 13/106

/ 13/2

/ 13/51

/ 14

/ 14/63

/ 38