Journal Article

Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode

Jiao, Qing, Zhu, Ce, Lu, Shaojia, Cui, Dong, Su, Linyan, Yang, Rongwang, Gao, Weijia, Chen, Yue

2024

Overview

Background Bipolar disorder may begin as depression or mania, which can affect the treatment and prognosis. The physiological and pathological differences among pediatric bipolar disorder (PBD) patients with different onset symptoms are not clear. The aims of the present study were to investigate subcortical structural alterations in PBD patients with first-episode depressive (PBD-FED) and first-episode manic (PBD-FEM). Methods A total of 59 individuals including 28 PBD-FED, 13 PBD-FEM, and 18 healthy controls (HCs) underwent high-resolution structural magnetic resonance scans. FreeSurfer 7.2 was used to detect changes in subcortical volumes. Simultaneously, thalamic, hippocampal, and amygdala subregion volumes were compared between the three groups. Results Analysis of covariance controlling for age, sex, education, and estimated intracranial volume shows third and fourth ventricle enlargement in patients with PBD. Compared with the PBD-FED and HCs, the PBD-FEM group had reduced gray matter volume in the left thalamus, bilateral hippocampus, and right amygdala. Subsequent subregion analyses showed right cortico-amygdaloid transient, bilateral accessory-basal nucleus, left hippocampal tail, right hippocampal head, and body volume reduction in the PBD-FEM group. Conclusions The present findings provided evidence of decreased subcortical structure in PBD-FEM patients, which might present its trait feature.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Affective disorders / Amygdala / Amygdala - diagnostic imaging / Amygdala - pathology / Analysis / Bipolar disorder / Bipolar Disorder - diagnostic imaging / Bipolar Disorder - pathology / Brain - diagnostic imaging / Brain - pathology / Brain research / Care and treatment / Child / Child & adolescent mental health / Child psychopathology / Demographic aspects / Diagnosis / Diseases / Electroconvulsive therapy / Family medical history / Female / First-episode symptoms / Gray Matter - diagnostic imaging / Gray Matter - pathology / Hippocampus / Hippocampus - diagnostic imaging / Hippocampus - pathology / Humans / Intelligence / Magnetic Resonance Imaging / Male / Mania - diagnostic imaging / Mania - pathology / Medicine / Medicine & Public Health / Mental disorders / Organ Size / Pathophysiology / Patients / Pediatrics / Physiology, Pathological / Psychiatry / Psychosis / Psychotherapy / Questionnaires / Relapse / Schizophrenia / Structure magnetic resonance imaging / Subcortical structures / Substantia grisea / Thalamus / Thalamus - diagnostic imaging / Thalamus - pathology / Ventricles (cerebral)