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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

by Guiguen, Yann , Grimm, Sara A , Institut National de la Santé et de la Recherche Médicale (Inserm) (France) , ANR-16-CE14-0020,SexMaintain,Rôle de TRIM28 dans le maintien de l'identité ovarienne et dans la détermination du sexe , Pailhoux, Eric , Université Paris-Saclay , Capel, Blanche , Yao, Humphrey H. -C , Dupin-De-Beyssat, Elodie , National Science Foundation in the US - National Science Foundation (NSF) [IOS-1256675] , French National Research Agency (ANR) [ANR-16-CE14-0020] , Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique) , Lecluze, Estelle , Nicol, Barbara , Chalmel, Fréderic , Biologie du Développement et Reproduction (BDR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA) , Ecole des Hautes Etudes en Sante Publique (EHESP) (France) , Institut de recherche en santé, environnement et travail (Ir

in 13/51 / 14/19 / 14/35 / 38/77 / 45/15 / 45/61 / 631/136/142 / 631/208/200 / 631/443/494 / 64/110 / 64/60 / Animals / Animals, Newborn / Base Sequence / Cell differentiation / Cell lineage / Chromatin / Chromatin - metabolism / Core Binding Factor Alpha 2 Subunit - genetics / Core Binding Factor Alpha 2 Subunit - metabolism / Environmental health / Female / Fetus - metabolism / Fetuses / Forkhead Box Protein L2 - metabolism / Gene expression / Genome / Genomics / Gonads / Granulosa cells / Granulosa Cells - metabolism / Health sciences / Humanities and Social Sciences / Life Sciences / Mice / Mice, Knockout / Mice, Transgenic / multidisciplinary / Occupancy / Oncorhynchus mykiss / Ovaries / Ovary - embryology / Runx1 protein / Science / Science (multidisciplinary) / Sertoli cells / Sex determination / SOX9 Transcription Factor - metabolism / Specifications / Transcription factors / Transcriptome - genetics / Trout / Vertebrates

2019

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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

2019

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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

2019

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Journal Article

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Guiguen, Yann,

Grimm, Sara A,

Institut National de la Santé et de la Recherche Médicale (Inserm) (France),

ANR-16-CE14-0020,SexMaintain,Rôle de TRIM28 dans le maintien de l'identité ovarienne et dans la détermination du sexe,

Pailhoux, Eric,

Université Paris-Saclay,

Capel, Blanche,

Yao, Humphrey H. -C,

Dupin-De-Beyssat, Elodie,

National Science Foundation in the US - National Science Foundation (NSF) [IOS-1256675],

French National Research Agency (ANR) [ANR-16-CE14-0020],

Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique),

Lecluze, Estelle,

Nicol, Barbara,

Chalmel, Fréderic,

Biologie du Développement et Reproduction (BDR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA),

Ecole des Hautes Etudes en Sante Publique (EHESP) (France),

Institut de recherche en santé, environnement et travail (Ir

2019

Overview

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the supporting cell lineage and becomes pre-granulosa cell-specific as the gonads differentiate. RUNX1 plays complementary/redundant roles with FOXL2 to maintain fetal granulosa cell identity and combined loss of RUNX1 and FOXL2 results in masculinization of fetal ovaries. At the chromatin level, RUNX1 occupancy overlaps partially with FOXL2 occupancy in the fetal ovary, suggesting that RUNX1 and FOXL2 target common sets of genes. These findings identify RUNX1, with an ovary-biased expression pattern conserved across species, as a regulator in securing the identity of ovarian-supporting cells and the ovary.

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Publisher

Nature Publishing Group,HAL CCSD,Nature Publishing Group UK,Nature Portfolio

Subject

13/51

/ 14/19

/ 14/35

/ 38/77

/ 45/15

/ 45/61

/ 631/136/142