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Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
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Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
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Journal Article
Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
2012
Overview
The molecular characterization of cytogenetic abnormalities has not only provided insights into the mechanisms of leukemogenesis but also led to the establishment of new treatment strategies targeting these abnormalities and thereby further improve the prognosis of patients. We analyzed the prognosis of 1091 Chinese patients with newly diagnosed acute lymphoblastic leukemia (ALL) and explored the prognostic impacts of a large number of cytogenetic/molecular abnormalities. It was demonstrated that, in both B- and T-ALL settings, the prognosis was negatively correlated to the age as reported to date. For childhood T-ALL patients, it was also documented that the
HOX11
expression represented a favorable prognostic factor as it was in adult ones. We identified
CRLF2
overexpression as an intermediate-risk marker and
Ik6
variant of
IKZF1
gene as a high-risk one when stratifying pediatric B-ALL cases according to cytogenetic/molecular risks. We also found that
Ik6
variant and
CRLF2
overexpression had an important role in dictating the prognosis of Ph-negative patients, which may be useful markers in guiding the treatment of ALL in the future, with tyrosine kinase inhibitors on the other hand reversing the fate of Ph-positive ALL patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acute lymphoblastic leukemia
/ Adult
/ Aged
/ Biological and medical sciences
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Child
/ Children
/ China
/ Female
/ Genomics
/ Hematologic and hematopoietic diseases
/ Humans
/ Identification and classification
/ Infant
/ Kinases
/ Leukemia
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Male
/ Markers
/ Medicine
/ Oncology
/ Patients
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism
/ Tyrosine
