Journal Article

ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample: the SAPRIS-SERO multi-cohort study

Esseddik, Younes, Severi, Gianluca, Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Szabo de Edelenyi, Fabien, Università degli Studi di Firenze = University of Florence = Université de Florence (UniFI), Srour, Bernard, SAPRIS-SERO study group: Fabrice Carrat, Pierre-Yves Ancel, Nathalie Bajos, Marie-Aline Charles, Gianluca Severi, Mathilde Touvier, Marie Zins, Sofiane Kab, Adeline Renuy, Stéphane Le Got, Céline Ribet, Mireille Pellicer, Emmanuel Wiernik, Marcel Goldberg, Marie Zins, Fanny Artaud, Pascale Gerbouin-Rérolle, Mélody Enguix, Camille Laplanche, Roselyn Gomes-Rimav, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Gianluca Severi, Fabien Szabo de Edelenyi, Julien Allègre, Nathalie Druesne-Pecollo, Younes Esseddik, Serge Her

2023

Overview

Abstract ABO blood type has been reported as a potential factor influencing SARS-CoV-2 infection, but so far mostly in studies that involved small samples, selected population and/or used PCR test results. In contrast our study aimed to assess the association between ABO blood types and SARS-CoV-2 infection using seroprevalence data (independent of whether or not individuals had symptoms or sought for testing) in a large population-based sample. Our study included 67,340 French participants to the SAPRIS-SERO multi-cohort project. Anti-SARS-CoV-2 antibodies were detected using ELISA (targeting the proteins spike (S) and nucleocapsid (NP)) and seroneutralisation (SN) tests on dried blood spots collected in May–November 2020. Non-O individuals (and especially types A and AB) were more likely to bear anti SARS-CoV-2 antibodies (ELISA-S, 2964 positive cases: OR non-Ovs.O = 1.09[1.01–1.17], OR Avs.O = 1.08[1.00–1.17]; ELISA-S/ELISA-NP/SN, 678 triple positive cases: OR non-Ovs.O = 1.19 [1.02–1.39], OR Avs.O = 1.19[1.01–1.41], OR ABvs.O = 1.43[1.01–2.03]). Hence, our results provided additional insights into the dynamic of SARS-CoV-2 infection, highlighting a higher susceptibility of infection for individuals of blood types A and AB and a lesser risk for blood type O.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 692/308/174 / 692/499 / 692/699/255/2514 / ABO Blood-Group System - immunology / ABO system / Adolescent / Adult / Aged / Antibodies / Antibodies, Viral - immunology / Blood / Blood groups / Cohort analysis / Cohort Studies / COVID-19 / COVID-19 - epidemiology / COVID-19 - immunology / COVID-19 Serological Testing / Female / Humanities and Social Sciences / Humans / Infections / Life Sciences / Male / Middle Aged / multidisciplinary / Nucleocapsids / Population studies / Population-based studies / Science / Science (multidisciplinary) / Seroepidemiologic Studies / Serology / Severe acute respiratory syndrome coronavirus 2 / Young Adult
• ISBN: 0010240336000