Journal Article

Resting state functional atlas and cerebral networks in mouse lemur primates at 11.7 Tesla

Garin, Clément M., Landeau, Brigitte, Bougacha, Salma, Nadkarni, Nachiket A., Picq, Jean-Luc, Chételat, Gaël, Dhenain, Marc

2021

Overview

•Mouse lemur, one of the smallest primates, was imaged with high field 11.7T MRI.•First functional atlas of mouse lemur brain.•First characterization of its brain networks and comparison with human networks.•High-level cortical networks of lemurs are not homologous to human ones.•Hubs are grouped in lemurs while they are split into clusters in humans. Measures of resting-state functional connectivity allow the description of neuronal networks in humans and provide a window on brain function in normal and pathological conditions. Characterizing neuronal networks in animals is complementary to studies in humans to understand how evolution has modelled network architecture. The mouse lemur (Microcebus murinus) is one of the smallest and more phylogenetically distant primates as compared to humans. Characterizing the functional organization of its brain is critical for scientists studying this primate as well as to add a link for comparative animal studies. Here, we created the first functional atlas of mouse lemur brain and describe for the first time its cerebral networks. They were classified as two primary cortical networks (somato-motor and visual), two high-level cortical networks (fronto-parietal and fronto-temporal) and two limbic networks (sensory-limbic and evaluative-limbic). Comparison of mouse lemur and human networks revealed similarities between mouse lemur high-level cortical networks and human networks as the dorsal attentional (DAN), executive control (ECN), and default-mode networks (DMN). These networks were however not homologous, possibly reflecting differential organization of high-level networks. Finally, cerebral hubs were evaluated. They were grouped along an antero-posterior axis in lemurs while they were split into parietal and frontal clusters in humans. [Display omitted]

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Adult / Animal cognition / Animals / Atlases as Topic / Attention - physiology / Brain - diagnostic imaging / Brain - physiology / Brain architecture / Brain function / Brain research / Cerebral networks / Cheirogaleidae / Default Mode Network - diagnostic imaging / Default Mode Network - physiology / Dementia / Dictionaries / Executive function / Executive Function - physiology / Female / Functional morphology / Functional MRI / Functional Neuroimaging / Hubs / Humans / Life Sciences / Magnetic Resonance Imaging / Male / Memory / Microcebus murinus / Middle Aged / Mouse lemur atlas / Neural networks / Neural Pathways - diagnostic imaging / Neural Pathways - physiology / Neurobiology / Neurons and Cognition / Phylogeny / Primates / Questionnaires / Rest / Resting state / Scanners / Sensorimotor integration / Time series