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Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
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Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
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Journal Article
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
2020
Overview
HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n = 113), HIV-infected children (n = 54) had evidence (false discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-α-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p < 0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4017
/ 692/499
/ Children
/ Diet, High-Fat - adverse effects
/ Female
/ HIV
/ HIV Infections - epidemiology
/ Human immunodeficiency virus
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Lipid Metabolism - immunology
/ Male
/ Plasma
/ Science
/ Severe Acute Malnutrition - blood
/ Severe Acute Malnutrition - epidemiology
/ Severe Acute Malnutrition - immunology
