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Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod
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Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod
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Journal Article
Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod
2019
Overview
The genetic mechanisms determining sex in teleost fishes are highly variable and the master sex determining gene has only been identified in few species. Here we characterize a male-specific region of 9 kb on linkage group 11 in Atlantic cod (
Gadus morhua
) harboring a single gene named
zkY
for zinc knuckle on the Y chromosome. Diagnostic PCR test of phenotypically sexed males and females confirm the sex-specific nature of the Y-sequence. We identified twelve highly similar autosomal gene copies of
zkY
, of which eight code for proteins containing the zinc knuckle motif. 3D modeling suggests that the amino acid changes observed in six copies might influence the putative RNA-binding specificity. Cod zkY and the autosomal proteins zk1 and zk2 possess an identical zinc knuckle structure, but only the Y-specific gene
zkY
was expressed at high levels in the developing larvae before the onset of sex differentiation. Collectively these data suggest
zkY
as a candidate master masculinization gene in Atlantic cod. PCR amplification of Y-sequences in Arctic cod (
Arctogadus glacialis
) and Greenland cod (
Gadus macrocephalus ogac
) suggests that the male-specific region emerged in codfishes more than 7.5 million years ago.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/91
/ 45
/ 45/23
/ Animals
/ Female
/ Fish
/ Humanities and Social Sciences
/ Larvae
/ Male
/ RNA
/ Science
/ Sequence Alignment - methods
/ Sex Determination Processes - genetics
/ Zinc
