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Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

by Otte, A C J , Ohlraun, S , Tullius, M , Cichon, S , Nöthen, M M , Maier, W , Propping, P , Kovalenko, S , Abon Jamra, R , Freudenberg, J , Schumacher, J , Becker, T , Rietschel, M , Van Den Bogaert, A

in Acids / Adult / Adult and adolescent clinical studies / Amino acid oxidase / Behavioral Sciences / Biological and medical sciences / Biological Psychology / Bipolar disorder / Bipolar Disorder - epidemiology / Bipolar Disorder - genetics / Carrier Proteins - genetics / D-Amino-acid oxidase / D-Amino-Acid Oxidase - genetics / Depression / Female / Genes / Genetic Predisposition to Disease - epidemiology / Genotype & phenotype / Haplotypes / Humans / Hypotheses / Male / Medical sciences / Medicine / Medicine & Public Health / Mental disorders / Middle Aged / Mood disorders / Neurosciences / original-research-article / Pharmacotherapy / Polymorphism, Single Nucleotide / Psychiatry / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Psychoses / Risk Factors / Schizophrenia / Schizophrenia - epidemiology / Schizophrenia - genetics / Single-nucleotide polymorphism

2004

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Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

2004

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Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

2004

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Journal Article

Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

Otte, A C J,

Ohlraun, S,

Tullius, M,

Cichon, S,

Nöthen, M M,

Maier, W,

Propping, P,

Kovalenko, S,

Abon Jamra, R,

Freudenberg, J,

Schumacher, J,

Becker, T,

Rietschel, M,

Van Den Bogaert, A

2004

Overview

A recent study has suggested that the brain-expressed genes for G72 and D -amino-acid oxidase (DAAO) exert an influence on susceptibility to schizophrenia. Our aim was to replicate this finding in German schizophrenic patients and to assess whether G72 and DAAO might also contribute to the development of bipolar affective disorder. We genotyped seven single-nucleotide polymorphisms (SNPs) in the G72 gene and three in the DAAO gene in 599 patients (299 schizophrenic, 300 bipolar) and 300 controls. At G72, individual SNPs and a four-marker haplotype were associated with schizophrenia. The most significant SNP as well as the haplotype were also associated with bipolar affective disorder (BPAD). DAAO was associated with schizophrenia, but not with BPAD. The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

Acids

/ Adult

/ Adult and adolescent clinical studies

/ Amino acid oxidase

/ Behavioral Sciences

/ Biological and medical sciences

/ Biological Psychology