Asset Details
Do you wish to reserve the book?
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
Do you wish to request the book?
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
2021
Overview
We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and metabolic syndrome are unclear. Here we show that in both mice and humans, adipose mitochondrial functions are elevated in females and are strongly associated with adiposity, insulin resistance and plasma lipids. Using a panel of diverse inbred strains of mice, we identify a genetic locus on mouse chromosome 17 that controls mitochondrial mass and function in adipose tissue in a sex- and tissue-specific manner. This locus contains
Ndufv2
and regulates the expression of at least 89 mitochondrial genes in females, including oxidative phosphorylation genes and those related to mitochondrial DNA content. Overexpression studies indicate that
Ndufv2
mediates these effects by regulating supercomplex assembly and elevating mitochondrial reactive oxygen species production, which generates a signal that increases mitochondrial biogenesis.
Chella Krishnan et al. demonstrate sex-specific regulation of adipose tissue mitochondrial function that contributes to sex differences in susceptibility to metabolic syndrome traits.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 13/44
/ 38/43
/ 38/61
/ 38/90
/ 38/91
/ 59
/ 64/60
/ 82/29
/ 96/34
/ 96/44
/ Animals
/ Biomedical and Life Sciences
/ Body fat
/ Cardiology and cardiovascular system
/ Female
/ Females
/ Genomes
/ Humans
/ Lipids
/ Liver
/ Male
/ Males
/ Metabolic Syndrome - diagnosis
/ Metabolic Syndrome - etiology
/ Metabolic Syndrome - metabolism
/ Mice
/ NADH Dehydrogenase - genetics
/ NADH Dehydrogenase - metabolism
/ Obesity
/ Polymorphism, Single Nucleotide
/ Quantitative Trait, Heritable
/ Reactive Oxygen Species - metabolism
/ Sexes
