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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
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Journal Article
Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
2006
Overview
Although primary and memory responses against bacteria and viruses have been studied extensively, T helper type 2 (TH2) effector mechanisms leading to host protection against helminthic parasites remain elusive1. Examination of the intestinal epithelial submucosa of mice after primary and secondary infections by a natural gastrointestinal parasite revealed a distinct immune-cell infiltrate after challenge, featuring interleukin-4-expressing memory CD4+ T cells that induced IL-4 receptorhi (IL-4Rhi) CD206+ alternatively activated macrophages2. In turn, these alternatively activated macrophages (AAMacs) functioned as important effector cells of the protective memory response contributing to parasite elimination, demonstrating a previously unknown mechanism for host protection against intestinal helminths.
