Journal Article

Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions

Roy, Partha, Das, Suvadra, Mukherjee, Arup, Ghosh Auddy, Runa

2014

Overview

Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activity. The application of AG in therapeutics, however, is severely constrained, due to its low aqueous solubility, short biological half-life, and poor cellular permeability. Engineered nanoparticles in biodegradable polymer systems were therefore conceived as one solution to aid in further drug-like applications of AG. In this study, a cationic modified poly(lactic-co-glycolic) acid nanosystem was applied for evaluation against experimental mouse hepatotoxic conditions. Biopolymeric nanoparticles of hydrodynamic size of 229.7 ± 17.17 nm and ζ-potential +34.4 ± 1.87 mV facilitated marked restoration in liver functions and oxidative stress markers. Superior dissolution for bioactive AG, hepatic residence, and favorable cytokine regulation in the liver tissues are some of the factors responsible for the newer nanosystem-assisted rapid recovery.

• Publisher: Dove Medical Press Limited,Taylor & Francis Ltd,Dove Press,Dove Medical Press
• Subject: Andrographis - chemistry / Andrographis paniculata / andrographolide / Animals / Antioxidants - metabolism / Cancer / Carbon Tetrachloride - toxicity / Care and treatment / Chemical and Drug Induced Liver Injury - metabolism / Chromatography / cytokine regulation / Cytokines - metabolism / Deoxyribonucleic acid / Diterpenes - chemistry / Diterpenes - pharmacology / DNA / Drug delivery systems / engineered nanosystems / Ethanol / Free radicals / hepatotoxicity / Herbal medicine / Lactic Acid - chemistry / Lipid Peroxidation - drug effects / Lipids / Liver - drug effects / Liver - pathology / Liver diseases / Male / Mice / Nanoparticles / Nanoparticles - chemistry / Nanotechnology / Original Research / Oxidative stress / Oxidative Stress - drug effects / Particle Size / Pharmaceuticals / Plant Extracts - chemistry / Plant Leaves - chemistry / poly(lactic-co-glycolic) acid / Polyglycolic Acid - chemistry / Properties