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A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer
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A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer
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A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer
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Journal Article
A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer
2024
Overview
Background
Cervical cancer (CC) is a common malignancy of the female reproductive tract, and preoperative prediction of lymph node metastasis (LNM) is essential. This study aims to design and validate a magnetic resonance imaging (MRI) radiomics-based predictive model capable of detecting LNM in patients diagnosed with CC.
Methods
This retrospective analysis incorporated 86 and 38 CC patients into the training and testing groups, respectively. Radiomics features were extracted from MRI T2WI, T2WI-SPAIR, and axial apparent diffusion coefficient (ADC) sequences. Selected features identified in the training group were then used to construct a radiomics scoring model, with relevant LNM-related risk factors having been identified through univariate and multivariate logistic regression analyses. The resultant predictive model was then validated in the testing cohort.
Results
In total, 16 features were selected for the construction of a radiomics scoring model. LNM-related risk factors included worse differentiation (
P
< 0.001), more advanced International Federation of Gynecology and Obstetrics (FIGO) stages (
P
= 0.03), and a higher radiomics score from the combined MRI sequences (
P
= 0.01). The equation for the predictive model was as follows: −0.0493–2.1410 × differentiation level + 7.7203 × radiomics score of combined sequences + 1.6752 × FIGO stage. The respective area under the curve (AUC) values for the T2WI radiomics score, T2WI-SPAIR radiomics score, ADC radiomics score, combined sequence radiomics score, and predictive model were 0.656, 0.664, 0.658, 0.835, and 0.923 in the training cohort, while these corresponding AUC values were 0.643, 0.525, 0.513, 0.826, and 0.82 in the testing cohort.
Conclusions
This MRI radiomics-based model exhibited favorable accuracy when used to predict LNM in patients with CC. Relative to the use of any individual MRI sequence-based radiomics score, this predictive model yielded superior diagnostic accuracy.
