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Transmission of trained immunity and heterologous resistance to infections across generations
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Transmission of trained immunity and heterologous resistance to infections across generations
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Journal Article
Transmission of trained immunity and heterologous resistance to infections across generations
2021
Overview
Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with
Candida albicans
or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous
Escherichia coli
and
Listeria monocytogenes
infections. Sperm DNA of parental male mice intravenously infected with the fungus
C. albicans
showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections.
Transgenerational transmission of acquired immunological traits has been demonstrated in invertebrates and plants but not mammals. Katzmarski et al. demonstrate that trained immunity that protects against heterologous infections can be transmitted to F2 offspring.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 631/326
/ 631/337
/ Animals
/ Biomedical and Life Sciences
/ Candida albicans - immunology
/ Candida albicans - pathogenicity
/ DNA
/ E coli
/ Escherichia coli - immunology
/ Escherichia coli - pathogenicity
/ Escherichia coli Infections - genetics
/ Escherichia coli Infections - immunology
/ Escherichia coli Infections - metabolism
/ Escherichia coli Infections - microbiology
/ Heredity
/ Immunity
/ Intergenerational transmission
/ Listeria monocytogenes - immunology
/ Listeria monocytogenes - pathogenicity
/ Male
/ Mammals
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