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GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair

by Zhang, Hui , Chen, Xiaoyan , Hu, Yangnan , Cheng, Hong , Guo, Jiamin , Xie, Jingdun , Lu, Weicheng , Zhang, Chen , Wang, Yan , Wang, Huan , Huang, Zhichun , Xia, Lin , Cai, Jiaying , Chai, Renjie , Xia, Yu

in Aqueous solutions / Axons / Biocompatibility / Biotechnology / Care and treatment / Cell differentiation / Cell proliferation / Chemistry / Chemistry and Materials Science / Composite materials / Conductive hydrogel / Cytotoxicity / Electric properties / Electrical conductivity / Electrical raceways / Electrical resistivity / Gels (Pharmacy) / Grooves / Hydrogels / Medical research / Microenvironments / Microgroove structure / Microscopy / Molecular Medicine / MXene / MXenes / Nanotechnology / Nerves / Neural stem cells / Neurons / Physiological aspects / Spinal cord injuries / Spinal cord injury / Stem cells / Structure / Testing

2022

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2022

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2022

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Journal Article

GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair

Zhang, Hui,

Chen, Xiaoyan,

Hu, Yangnan,

Cheng, Hong,

Guo, Jiamin,

Xie, Jingdun,

Lu, Weicheng,

Zhang, Chen,

Wang, Yan,

Wang, Huan,

Huang, Zhichun,

Xia, Lin,

Cai, Jiaying,

Chai, Renjie,

Xia, Yu

2022

Overview

Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Axons

/ Cell differentiation

/ Cell proliferation