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Upregulated Ras/Raf/ERK1/2 signaling pathway： a new hope in the repair of spinal cord injury
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Upregulated Ras/Raf/ERK1/2 signaling pathway： a new hope in the repair of spinal cord injury
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Journal Article
Upregulated Ras/Raf/ERK1/2 signaling pathway： a new hope in the repair of spinal cord injury
2015
Overview
An increasing number of studies report that the Ras/Raf/extracellular signal-regulated kinase 1/2 （ERK1/2） signaling pathway has a death-promoting apoptotic function in neural cells. We hypothesized that the Ras/Raf/ERK1/2 signaling pathway may be abnormally regulated in rat injured spinal cord models. The weight drop method was used to establish rat spinal cord injury at T9. Western blot analysis and immunohistochemical staining revealed Ras expression was dramatically elevated, and the phosphorylations of A-Raf, B-Raf and C-Raf were all upregulated in the injured spinal cord. Both mitogen-activated protein kinase kinase 1/2 and ERK1/2, which belong to the Ras/Raf signaling kinases, were upregulated. These results indicate that Ras/Raf/ ERK1/2 signaling may be upregulated in injured spinal cord and are involved in recovery after spinal cord injury.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Department of 0rthopedics, General Hospital of Tianjin Medical University, Tianjin, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
Subject
/ Analysis
/ apoplexy
/ Bcl-2
/ brain
/ brain-derived neurotrophic factor
/ Cellular signal transduction
/ cerebral ischemia/reperfusion injury
/ cerebral subarachnoid hemorrhage
/ divalent metal transporter 1
/ ERK1／2
/ exosome
/ functional magnetic resonance imaging
/ GSK-3ß
/ healthy
/ hypoxic-ischemic brain damage
/ injury
/ ischemia
/ Kinases
/ lateral intracerebroventricular injection
/ Liprin-α
/ mice
/ microRNA
/ neuron
/ peroxisome proliferator-activated receptor gamma coactivator 1-alpha
/ PP2A
/ Proteins
/ Ras
/ Ras/Raf/Erk1/2 signaling pathway
/ repair
/ Software
/ SRY-related HMG box transcription factor 9
/ subacute
/ Syd-1
/ therapy
/ 信号通路
/ 免疫组织化学染色
/ 损伤修复
/ 脊髓损伤
