Journal Article

Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction

Mayrink, J., Cecatti, Jose Guilherme, Costa, Maria Laura

2018

Overview

Preeclampsia currently remains one of the leading causes of death and severe maternal morbidity. Although its prevalence is still underestimated in some places due to underreporting, preeclampsia is a disease that health professionals need to know how to deal with and take action. For this reason, the studies about the theme remain along with the advances in their understanding that often implies improvement and change of concepts and conducts. The complexity of its etiology is a challenge and requires further studies for its full understanding. Apparently, poor adaptation of the maternal organism to the conceptus, marked by the nonoccurrence of changes in the uterine spiral arteries, determines a series of systemic repercussions that compound the various forms of preeclampsia presentation. In recent years, the use of acetylsalicylic acid to prevent cases of early onset of the disease has been consolidated and, alongside, studies have advanced the development of accessible and effective methods of identifying women at risk of preeclampsia. The aim of this review is to discuss updates on the occurrence, concept, pathophysiology, repercussion, prevention, and prediction of preeclampsia.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc,Hindawi Limited,Wiley
• Subject: Acetylsalicylic acid / ADAM12 Protein - genetics / ADAM12 Protein - metabolism / Adult / Anti-Inflammatory Agents, Non-Steroidal - therapeutic use / Antihypertensive Agents - therapeutic use / Arteries / Aspirin / Aspirin - therapeutic use / Biomarkers / Biomarkers - metabolism / Blood pressure / Death / Etiology / Etiology (Medicine) / Female / Galectins - genetics / Galectins - metabolism / Health / Health risk assessment / High income / Humans / Hypertension / Identification methods / Laser-Doppler Flowmetry / Low income groups / Maternal mortality / Medical personnel / Membrane Proteins - genetics / Membrane Proteins - metabolism / Morbidity / Obstetrics / Placenta - blood supply / Placenta - diagnostic imaging / Placenta - drug effects / Placenta - physiopathology / Pre-eclampsia / Pre-Eclampsia - diagnostic imaging / Pre-Eclampsia - genetics / Pre-Eclampsia - physiopathology / Pre-Eclampsia - prevention & control / Preeclampsia / Pregnancy / Pregnancy Proteins - genetics / Pregnancy Proteins - metabolism / Pregnancy-Associated Plasma Protein-A - genetics / Pregnancy-Associated Plasma Protein-A - metabolism / Prevalence studies (Epidemiology) / Prognosis / Review / Risk Factors / Salicylates / Urine / Uterine Artery - diagnostic imaging / Uterine Artery - drug effects / Uterine Artery - physiopathology / Uterus / Vascular Endothelial Growth Factor Receptor-1 - genetics / Vascular Endothelial Growth Factor Receptor-1 - metabolism / Womens health