Asset Details
Do you wish to reserve the book?
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Do you wish to request the book?
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
2001
Overview
Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed that expression of ABC transporters is responsible for this phenotype, the specific molecules involved have not been defined. Here we show that expression of the
Bcrp1
(also known as
Abcg2
murine/
ABCG2
human) gene is a conserved feature of stem cells from a wide variety of sources.
Bcrp1
mRNA was expressed at high levels in primitive murine hematopoietic stem cells, and was sharply downregulated with differentiation. Enforced expression of the
ABCG2
cDNA directly conferred the SP phenotype to bone-marrow cells and caused a reduction in maturing progeny both
in vitro
and in transplantation-based assays. These results show that expression of the
Bcrp1
/
ABCG2
gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ ATP Binding Cassette Transporter, Sub-Family G, Member 2
/ ATP-Binding Cassette Transporters - genetics
/ ATP-Binding Cassette Transporters - metabolism
/ ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
/ ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism
/ Biomedical and Life Sciences
/ Bone Marrow Cells - physiology
/ Female
/ Humans
/ Macrophage Inflammatory Proteins
/ Male
/ Mice
/ Multidrug Resistance-Associated Proteins
