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Metabolic reprogramming in triple-negative breast cancer
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Metabolic reprogramming in triple-negative breast cancer
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Metabolic reprogramming in triple-negative breast cancer
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Journal Article
Metabolic reprogramming in triple-negative breast cancer
2020
Overview
Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing studies have focused on its genetic and molecular characteristics. Patients diagnosed with TNBC, compared to those diagnosed with other breast cancer subtypes, have relatively poor outcomes due to high tumor aggressiveness and lack of targeted treatment. Metabolic reprogramming, an emerging hallmark of cancer, is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands; maintain the redox balance; and further promote oncogenic signaling, cell proliferation, and metastasis. Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC. Here, we review the metabolic reprogramming of glycolysis, oxidative phosphorylation, amino acid metabolism, lipid metabolism, and other branched pathways in TNBC and explore opportunities for new biomarkers, imaging modalities, and metabolically targeted therapies.
Publisher
Chinese Anti-Cancer Association (CACA), Cancer Biology & Medicine,Department of Pathology and Pathophysiology, Zhejiang University School of Medicine,Hangzhou 310058, China,Department of Surgical Oncology(Breast Center)of The Second Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou 310058, China%Department of Pathology and Pathophysiology, Zhejiang University School of Medicine,Hangzhou 310058, China%Department of Surgical Oncology(Breast Center)of The Second Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou 310058, China,Compuscript,China Anti-Cancer Association
Subject
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ Biomarkers, Tumor - analysis
/ Biomarkers, Tumor - metabolism
/ Enzymes
/ Female
/ Glucose
/ Humans
/ Kinases
/ Lipid Metabolism - drug effects
/ Molecular Targeted Therapy - methods
/ Oxidative Phosphorylation - drug effects
/ Proteins
/ Review
/ Triple Negative Breast Neoplasms - diagnosis
/ Triple Negative Breast Neoplasms - drug therapy
/ Triple Negative Breast Neoplasms - pathology
