Asset Details
Do you wish to reserve the book?
TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum
Do you wish to request the book?
TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
TLR7 modulating B-cell immune responses in the spleen of C57BL/6 mice infected with Schistosoma japonicum
2021
Overview
B cells played an important role in Schistosoma infection-induced diseases. TLR7 is an intracellular member of the innate immune receptor. The role of TLR7 on B cells mediated immune response is still unclear. Here, C57BL/6 mice were percutaneously infected by S . japonicum for 5–6 weeks. The percentages and numbers of B cells increased in the infected mice ( p < 0.05), and many activation and function associated molecules were also changed on B cells. More splenic cells of the infected mice expressed TLR7, and B cells were served as the main cell population. Moreover, a lower level of soluble egg antigen (SEA) specific antibody and less activation associated molecules were found on the surface of splenic B cells from S . japonicum infected TLR7 gene knockout (TLR7 KO) mice compared to infected wild type (WT) mice ( p < 0.05). Additionally, SEA showed a little higher ability in inducing the activation of B cells from naive WT mice than TLR7 KO mice ( p < 0.05). Finally, the effects of TLR7 on B cells are dependent on the activation of NF-κB p65. Altogether, TLR7 was found modulating the splenic B cell responses in S . japonicum infected C57BL/6 mice.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Antigens
/ B cells
/ Cells
/ Female
/ Humans
/ Immune response (cell-mediated)
/ Immunity
/ Lymphoma
/ Medicine and Health Sciences
/ Mice
/ Rodents
/ Schistosoma japonicum - genetics
/ Schistosoma japonicum - physiology
/ Schistosomiasis japonica - genetics
/ Schistosomiasis japonica - immunology
/ Schistosomiasis japonica - parasitology
/ Spleen
/ TLR7
/ Toll-Like Receptor 7 - genetics
