Journal Article

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Rahmim, Arman, Courtney, Susan M., Brašić, James R., Wong, Dean F., Roberts, Joshua, Kuwabara, Hiroto, Anderson, Brian A.

2017

Overview

The attention system is shaped by reward history, such that learned reward cues involuntarily draw attention. Recent research has begun to uncover the neural mechanisms by which learned reward cues compete for attention, implicating dopamine (DA) signaling within the dorsal striatum. How these elevated priority signals develop in the brain during the course of learning is less well understood, as is the relationship between value-based attention and the experience of reward during learning. We hypothesized that the magnitude of the striatal DA response to reward during learning contributes to the development of a learned attentional bias towards the cue that predicted it, and examined this hypothesis using positron emission tomography with [11C]raclopride. We measured changes in dopamine release for rewarded versus unrewarded visual search for color-defined targets as indicated by the density and distribution of the available D2/D3 receptors. We then tested for correlations of individual differences in this measure of reward-related DA release to individual differences in the degree to which previously reward-associated but currently task-irrelevant stimuli impair performance in an attention task (i.e., value-driven attentional bias), revealing a significant relationship in the right anterior caudate. The degree to which reward-related DA release was right hemisphere lateralized was also predictive of later attentional bias. Our findings provide support for the hypothesis that value-driven attentional bias can be predicted from reward-related DA release during learning. •We related DA-release attributable to reward processing to distraction by reward cues.•Reward-related DA-release in the right anterior caudate predicted later distraction.•The right anterior caudate uniquely contributed to attentional capture by reward cues.•The attention-related effects of reward on DA-release exhibited right hemisphere dominance.•Our findings provide neural evidence linking reward processing to attentional learning.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Adult / Attention task / Attentional Bias - physiology / Bias / Caudate Nucleus - diagnostic imaging / Caudate Nucleus - metabolism / Caudate-putamen / Cocaine / Dopamine / Dopamine - metabolism / Dopamine D2 receptors / Dopamine D3 receptors / Dopamine receptors / Dopamine release positron emission tomography / Experiments / Feedback / Female / Hemispheric laterality / Humans / Incentive salience / Learning / Magnetic Resonance Imaging / Male / Medical imaging / Neostriatum / Positron emission tomography / Positron-Emission Tomography - methods / Psychomotor Performance - physiology / Raclopride / Radiopharmaceuticals / Reinforcement / Reward / Reward learning / Selective attention / Visual perception / Visual task performance / Young Adult