Journal Article

Comparison of the Antihypertensive Activity of Phenolic Acids

Yesol Jeon, Minjun Kim, Hana Lee, Junsoo Lee, Hyun Joo Kim, Huijin Heo, Myeongnam Yu

2022

Overview

Phenolic acids, found in cereals, legumes, vegetables, and fruits, have various biological functions. We aimed to compare the antihypertensive potential of different phenolic acids by evaluating their ACE inhibitory activity and cytoprotective capacity in EA.hy 926 endothelial cells. In addition, we explored the mechanism underlying the antihypertensive activity of sinapic acid. Of all the phenolic acids studied, sinapic acid, caffeic acid, coumaric acid, and ferulic acid significantly inhibited ACE activity. Moreover, gallic acid, sinapic acid, and ferulic acid significantly enhanced intracellular NO production. Based on the results of GSH depletion, ROS production, and MDA level analyses, sinapic acid was selected to study the mechanism underlying the antihypertensive effect. Sinapic acid decreases endothelial dysfunction by enhancing the expression of antioxidant-related proteins. Sinapic acid increased phosphorylation of eNOS and Akt in a dose-dependent manner. These findings indicate the potential of sinapic acid as a treatment for hypertension.

• Publisher: MDPI AG,MDPI
• Subject: ACE inhibition / Acids / Antihypertensive Agents / Antihypertensives / Antioxidants / Bioavailability / Blood pressure / Caffeic Acids / Cardiovascular disease / Care and treatment / Comparative analysis / Coumaric Acids / Cytotoxicity / Endothelial Cells / endothelial dysfunction / Endothelium / Enzymes / Gallic Acid / Health aspects / Hydroxybenzoates / Hypertension / Kinases / Lipid peroxidation / Nitric oxide / Organic chemistry / Oxidative stress / phenolic acids / phenolic acids; sinapic acid; ACE inhibition; hypertension; endothelial dysfunction / Phenols / Physiological aspects / Proteins / Proto-Oncogene Proteins c-akt / QD241-441 / Reactive Oxygen Species / Reagents / sinapic acid / Vegetables