Journal Article

The common sunstar Crossaster papposus: a neurotoxic starfish

Thomas, Krista M, Collin, Tom, Lewis, Adam M, Hatfield, Robert G, Hicks, Ruth, Lee, Vanessa, Alexander, Ryan P, White, Peter, Turner, Andrew D, Dean, Karl J, Teixeira Alves, Mickael, Coates, Lewis N, Daumich, Caroline, Ellis, Jim R

2021

Overview

Saxitoxins (STXs) are a family of potent neurotoxins produced naturally by certain species of phytoplankton and cyanobacteria which are extremely toxic to mammalian nervous systems. The accumulation of STXs in bivalve molluscs can significantly impact animal and human health. Recent work conducted in the North Sea highlighted the widespread presence of various saxitoxins in a range of benthic organisms, with the common sunstar (Crossaster papposus) demonstrating high concentrations of saxitoxins. In this study, an extensive sampling program was undertaken across multiple seas surrounding the UK, with 146 starfish and 5 brittlestars of multiple species analysed for STXs. All the common sunstars analysed (n > 70) contained quantifiable levels of STXs, with the total concentrations ranging from 99 to 11,245 µg STX eq/kg. The common sunstars were statistically different in terms of toxin loading to all the other starfish species tested. Two distinct toxic profiles were observed in sunstars, a decarbomylsaxitoxin (dcSTX)-dominant profile which encompassed samples from most of the UK coast and an STX and gonyautoxin2 (GTX2) profile from the North Yorkshire coast of England. Compartmentalisation studies demonstrated that the female gonads exhibited the highest toxin concentrations of all the individual organs tested, with concentrations >40,000 µg STX eq/kg in one sample. All the sunstars, male or female, exhibited the presence of STXs in the skin, digestive glands and gonads. This study highlights that the common sunstar ubiquitously contains STXs, independent of the geographical location around the UK and often at concentrations many times higher than the current regulatory limits for STXs in molluscs; therefore, the common sunstar should be considered toxic hereafter.

• Publisher: MDPI,MDPI AG
• Subject: Algae / animal and human health / Animals / Aquatic Organisms / Asteroidea / Bacteria / Benthos / Bivalvia / Body organs / coasts / Crossaster papposus / Cyanobacteria / Cysts / Digestive glands / England / Fatalities / Females / Genes / Geographical distribution / Geographical locations / Glands / Gonads / males / mammals / Marine mammals / Marine Toxins - analysis / Microorganisms / Mollusca / Mollusks / Neurotoxicity / Neurotoxins / Neurotoxins - analysis / north east Atlantic / North Sea / Ophiuroidea / Organs / paralytic shellfish toxins / Phytoplankton / Predation / Saxitoxin - analysis / saxitoxins / Seafood / Shellfish / Shellfish Poisoning / solasteridae / Species / Starfish / Statistical methods / sunstars / Taxonomy / Toxicity / Toxicity testing / Toxins / Water quality