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Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
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Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
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Journal Article
Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
2010
Overview
After a focal demyelination of the corpus callosum in adult mice, the demyelinated axons form functional excitatory synapses onto adult-born oligodendrocyte progenitor cells. This input is lost later on.
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2
+
oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon–oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
