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Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis
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Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis
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Journal Article
Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis
2019
Overview
Background
Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between EFT and DM, we conducted a meta-analysis of the relevant literature.
Methods
We systematically searched electronic databases for studies on EFT performed in DM patients and published up to 30 September 2018. We included data on EFT in a DM patient group and a non-DM control group. We then assessed the effect of DM on EFT by meta-analysis and trial sequential analysis (TSA). All statistical analyses were performed using Stata 12.0 and TSA software.
Results
A total of 13 studies (n = 1102 patients) were included in the final analysis. Compared with the control group, DM patients had significantly higher EFT (SMD: 1.23; 95% CI 0.98, 1.48; P = 0.000; TSA-adjusted 95% CI 0.91, 2.13;
P
< 0.0001). The TSA indicated that the available samples were sufficient and confirmed that firm evidence was reached. According to the regression analysis and subgroup analyses, DM typing, EFT ultrasound measurements, total cholesterol (TC) and triglyceride (TG) levels were confounding factors that significantly affected our results.
Conclusions
Our meta-analysis suggests that the amount of EFT is significantly higher in DM patients than in non-DM patients.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
Adipose Tissue - diagnostic imaging
/ Adipose Tissue - physiopathology
/ Adult
/ Aged
/ Diabetes
/ Diabetes Mellitus - diagnostic imaging
/ Diabetes Mellitus - epidemiology
/ Diabetes Mellitus - physiopathology
/ Female
/ Humans
/ Male
/ Medicine
/ NMR
/ Pericardium - diagnostic imaging
/ Pericardium - physiopathology
/ Typing
