Journal Article

Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation

Rozencwajg, Sacha, Jung, Jae-Seung, Sato, Noriko, Ainola, Carmen, Schmidt, Matthieu, Sato, Kei, Reid, Janice D., Livingstone, Samantha, Bouquet, Mahe, Palmieri, Chiara, Lorusso, Roberto, McGuire, Daniel, Wang, Xiaomeng, Helms, Leticia, Abbate, Gabriella, Colombo, Sebastiano Maria, Bassi, Gianluigi Li, Bartnikowski, Nicole, Heinsar, Silver, Vidal, Bruno, Suen, Jacky Y., Fraser, John F., Dyer, Wayne B., Wildi, Karin, Passmore, Margaret R., Ratsep, Indrek, Hyslop, Kieran, Wilson, Emily S.

2023

Overview

Differential hypoxaemia (DH) is common in patients supported by femoral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and can cause cerebral hypoxaemia. To date, no models have studied the direct impact of flow on cerebral damage. We investigated the impact of V-A ECMO flow on brain injury in an ovine model of DH. After inducing severe cardiorespiratory failure and providing ECMO support, we randomised six sheep into two groups: low flow (LF) in which ECMO was set at 2.5 L min −1 ensuring that the brain was entirely perfused by the native heart and lungs, and high flow (HF) in which ECMO was set at 4.5 L min −1 ensuring that the brain was at least partially perfused by ECMO. We used invasive (oxygenation tension—PbTO 2 , and cerebral microdialysis) and non-invasive (near infrared spectroscopy—NIRS) neuromonitoring, and euthanised animals after five hours for histological analysis. Cerebral oxygenation was significantly improved in the HF group as shown by higher PbTO 2 levels (+ 215% vs − 58%, p  = 0.043) and NIRS (67 ± 5% vs 49 ± 4%, p  = 0.003). The HF group showed significantly less severe brain injury than the LF group in terms of neuronal shrinkage, congestion and perivascular oedema ( p  < 0.0001 ) . Cerebral microdialysis values in the LF group all reached the pathological thresholds, even though no statistical difference was found between the two groups. Differential hypoxaemia can lead to cerebral damage after only a few hours and mandates a thorough neuromonitoring of patients. An increase in ECMO flow was an effective strategy to reduce such damages.

• Publisher: Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/443 / 631/443/1338 / 692/4019 / Animals / Biomedical and clinical sciences / Brain Injuries / Brain Injuries - complications / Brain injury / Edema / Extracorporeal Membrane Oxygenation / Extracorporeal Membrane Oxygenation - adverse effects / Humanities and Social Sciences / HYPEROXIA / HYPOXIA / Hypoxia - complications / Infrared spectroscopy / Medicine / Microdialysis / Models, Theoretical / multidisciplinary / NEUROLOGIC COMPLICATIONS / Neurology and neuromuscular diseases / Oxygenation / Q / R / Science / Science (multidisciplinary) / Sheep / Shock, Cardiogenic / Shock, Cardiogenic - etiology / Traumatic brain injury