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Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis
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Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis
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Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis
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Journal Article
Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis
2017
Overview
Background
Up to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed current systematic review and meta-analysis to clarify the controversial results.
Methods
Case-control studies reporting the relationship of rs9939609 A/T polymorphism and PCOS published before April 2015 were searched in Pubmed database without language restriction. Data was analyzed by Review Manager 5.2.
Results
A total of five studies involving 5010 PCOS patients and 5300 controls were included for further meta-analysis. The results of meta-analysis showed that the FTO gene rs9939609 A/T polymorphism was significantly different between PCOS group and control group in different gene models (For AA + AT vs. TT: OR = 1.41, 95% CI = 1.28–1.55,
P
< 0.00001. For AA vs. AT + TT: OR = 1.54, 95% CI = 1.25–1.89,
P
< 0.0001. For AA vs. TT: OR = 1.74, 95% CI = 1.38–2.18,
P
< 0.00001. For A vs. T: OR = 1.36, 95% CI = 1.25–1.47,
P
< 0.00001, respectively) suggesting that A allele was a risk factor for PCOS susceptibility. Furthermore, subgroup analysis in Asian and Caucasian ethnicities also found significant association between rs9939609 A/T polymorphism and PCOS (In Asian subgroup: OR = 1.43, 95% CI = 1.29–1.59,
P
< 0.0001. In Caucasian subgroup: OR = 1.33, 95% CI = 1.08–1.64,
P
= 0.008)
Conclusion
This meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with PCOS risk, and that A allele is a risk factor for PCOS susceptibility simultaneously.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Alleles
/ Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
/ Analysis
/ Biomedical and Life Sciences
/ Body fat
/ Diabetes
/ Female
/ FTO
/ Fto gene
/ Genes
/ Genetic epidemiology and genetic associations
/ Genetic Predisposition to Disease
/ Humans
/ Obesity
/ Polycystic Ovary Syndrome - complications
/ Polycystic Ovary Syndrome - genetics
/ Polymorphism, Single Nucleotide
/ Studies
