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Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features
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Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features
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Journal Article
Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features
2016
Overview
Background
The human lung tissue microbiota remains largely uncharacterized, although a number of studies based on airway samples suggest the existence of a viable human lung microbiota. Here we characterized the taxonomic and derived functional profiles of lung microbiota in 165 non-malignant lung tissue samples from cancer patients.
Results
We show that the lung microbiota is distinct from the microbial communities in oral, nasal, stool, skin, and vagina, with
Proteobacteria
as the dominant phylum (60 %). Microbiota taxonomic alpha diversity increases with environmental exposures, such as air particulates, residence in low to high population density areas, and pack-years of tobacco smoking and decreases in subjects with history of chronic bronchitis. Genus
Thermus
is more abundant in tissue from advanced stage (IIIB, IV) patients, while
Legionella
is higher in patients who develop metastases. Moreover, the non-malignant lung tissues have higher microbiota alpha diversity than the paired tumors.
Conclusions
Our results provide insights into the human lung microbiota composition and function and their link to human lifestyle and clinical outcomes. Studies among subjects without lung cancer are needed to confirm our findings.
Publisher
BioMed Central,Springer Nature B.V
Subject
/ air
/ Animal Genetics and Genomics
/ Biomedical and Life Sciences
/ Chronic obstructive pulmonary disease
/ DNA
/ Female
/ Genes
/ Genomes
/ Humans
/ Lung Neoplasms - complications
/ Lung Neoplasms - epidemiology
/ lungs
/ Male
/ Microbial Genetics and Genomics
/ nose
/ patients
/ Reproductive Tract Infections - complications
/ Reproductive Tract Infections - epidemiology
/ Reproductive Tract Infections - microbiology
/ RNA, Ribosomal, 16S - genetics
/ Skin
/ Studies
/ Taxonomy
/ Thermus
/ Tumors
/ Vagina
