Asset Details
Do you wish to reserve the book?
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
Do you wish to request the book?
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
2021
Overview
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. In the present study, we use functional and structural in vivo imaging in a mouse model of cortical MS to demonstrate that bouts of cortical inflammation disrupt cortical circuit activity coincident with a widespread, but transient, loss of dendritic spines. Spines destined for removal show local calcium accumulations and are subsequently removed by invading macrophages or activated microglia. Targeting phagocyte activation with a new antagonist of the colony-stimulating factor 1 receptor prevents cortical synapse loss. Overall, our study identifies synapse loss as a key pathological feature of inflammatory gray matter lesions that is amenable to immunomodulatory therapy.
Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 14/19
/ 14/28
/ 14/63
/ 14/69
/ 38/91
/ 64
/ 64/60
/ 82
/ 82/51
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Calcium
/ Cerebral Cortex - metabolism
/ Circuits
/ Colonies
/ Dendritic Spines - metabolism
/ Dendritic Spines - pathology
/ Macrophage colony-stimulating factor
/ Mice
/ Multiple Sclerosis - metabolism
/ Multiple Sclerosis - pathology
/ Structure-function relationships
/ Synapses
