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Prognostic value of NT-proBNP in patients with severe COVID-19
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Prognostic value of NT-proBNP in patients with severe COVID-19
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Prognostic value of NT-proBNP in patients with severe COVID-19
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Journal Article
Prognostic value of NT-proBNP in patients with severe COVID-19
2020
Overview
Background
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.
Methods
The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.
Results
The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.
Conclusion
NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.
Trial registration
ClinicalTrials,
NCT04292964.
Registered 03 March 2020,
Publisher
BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC
Subject
/ Aged
/ Clinical Laboratory Techniques
/ Coronavirus Infections - diagnosis
/ Coronavirus Infections - mortality
/ COVID-19
/ Death
/ Female
/ Humans
/ Male
/ Medicine
/ Natriuretic Peptide, Brain - analysis
/ Outcome
/ Patients
/ Peptide Fragments - analysis
/ Pneumology/Respiratory System
/ Pneumonia, Viral - diagnosis
/ Pneumonia, Viral - mortality
/ Severe acute respiratory syndrome coronavirus 2
/ Studies
