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FAPI-PET/CT guided radiotherapy for patients with esophageal cancer
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FAPI-PET/CT guided radiotherapy for patients with esophageal cancer
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Journal Article
FAPI-PET/CT guided radiotherapy for patients with esophageal cancer
2025
Overview
Background
Cancer associated fibroblasts have become a target of interest in different malignancies for positron emission tomography (PET) imaging, using positron emitter labelled fibroblast activation protein inhibitors (FAPI). New data underline the advanced imaging properties of FAPI-PET/CT for the staging of esophageal cancer compared to standard imaging. Potential benefits of FAPI-PET/CT in radiation therapy planning are the subject of this investigation.
Methods
Ten patients with newly diagnosed esophageal cancer treated with radiochemotherapy (RCT) were retrospectively analyzed. All patients underwent [68Ga]OncoFAP-PET/CT in treatment position to facilitate radiation treatment planning. Six patients received neoadjuvant RCT as part of a trimodal therapy and four patients underwent definitive RCT. In five cases, restaging after initial treatment was performed with FAPI-PET/CT.
Results
[68Ga]OncoFAP-PET/CT based imaging showed a high correlation with the endoscopic staging for initial imaging. In three cases, new sites of disease were unmasked, not visible in CT- and endosonographic staging. [68Ga]OncoFAP-PET/CT based RT delineation offered good definition of clinical target volumes, especially in retro-/paracardial areas and the gastroesophageal junction.
Conclusion
[68Ga]OncoFAP-PET/CT may aid and improve radiation treatment planning for patients with esophageal cancer.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Biopsy
/ Cancer
/ Emitters
/ Esophageal Neoplasms - diagnostic imaging
/ Esophageal Neoplasms - pathology
/ Esophageal Neoplasms - radiotherapy
/ FAPI
/ Female
/ Fibroblast activation protein
/ Humans
/ Imaging
/ Male
/ Membrane Proteins - antagonists & inhibitors
/ Methods
/ Oncology
/ Patients
/ PET
/ Planning
/ Positron emission tomography
/ Positron Emission Tomography Computed Tomography - methods
/ Radiotherapy Planning, Computer-Assisted - methods
/ Radiotherapy, Image-Guided - methods
/ Tumors
