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Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

by Anastasiades, Paul G , Butt, Simon JB , Molnar, Zoltan , Hoerder-Suabedissen, Anna , Lyngholm, Daniel , Marques-Smith, Andre , Vagnoni, Cristiana , Parameswaran, Gokul , Nakagawa, Yasushi , Ghezzi, Filippo , Rowett, Alexandra

in Animals / Animals, Newborn / Axons / Axons - metabolism / Cell death / Circuits / Cortex (somatosensory) / Electric Stimulation - methods / GABA Agents - metabolism / Green Fluorescent Proteins - metabolism / Information processing / Innervation / laser scanning photostimulation / Mice / Morphology / Neocortex / neural circuits / neural development / Neural networks / Neurons / Neurons - metabolism / Neuroscience / optogenetics / Optogenetics - methods / Physiology / Receptors, Lysophosphatidic Acid - metabolism / Sensory integration / Somatosensory Cortex - metabolism / subplate / Thalamus / Thalamus - metabolism / Vibrissae - metabolism

2021

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Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

2021

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Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

2021

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Journal Article

Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

Anastasiades, Paul G,

Butt, Simon JB,

Molnar, Zoltan,

Hoerder-Suabedissen, Anna,

Lyngholm, Daniel,

Marques-Smith, Andre,

Vagnoni, Cristiana,

Parameswaran, Gokul,

Nakagawa, Yasushi,

Ghezzi, Filippo,

Rowett, Alexandra

2021

Overview

Subplate neurons (SPNs) are thought to play a role in nascent sensory processing in neocortex. To better understand how heterogeneity within this population relates to emergent function, we investigated the synaptic connectivity of Lpar1-EGFP SPNs through the first postnatal week in whisker somatosensory cortex (S1BF). These SPNs comprise of two morphological subtypes: fusiform SPNs with local axons and pyramidal SPNs with axons that extend through the marginal zone. The former receive translaminar synaptic input up until the emergence of the whisker barrels, a timepoint coincident with significant cell death. In contrast, pyramidal SPNs receive local input from the subplate at early ages but then – during the later time window – acquire input from overlying cortex. Combined electrical and optogenetic activation of thalamic afferents identified that Lpar1-EGFP SPNs receive sparse thalamic innervation. These data reveal components of the postnatal network that interpret sparse thalamic input to direct the emergent columnar structure of S1BF.

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Publisher

eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd

Subject

/ Axons

/ Cortex (somatosensory)