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Transplacental transmission of SARS-CoV-2 infection
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Transplacental transmission of SARS-CoV-2 infection
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Journal Article
Transplacental transmission of SARS-CoV-2 infection
2020
Overview
SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.
Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/1
/ 14/63
/ 38
/ 38/77
/ 59
/ Coronavirus Infections - diagnosis
/ Coronavirus Infections - pathology
/ Coronavirus Infections - transmission
/ COVID-19
/ Female
/ Fetuses
/ Humanities and Social Sciences
/ Humans
/ Infectious Disease Transmission, Vertical
/ Male
/ Maternal-Fetal Exchange - physiology
/ Microbiology and Parasitology
/ Mothers
/ Neonates
/ Placenta
/ Pneumonia, Viral - diagnosis
/ Pneumonia, Viral - pathology
/ Pneumonia, Viral - transmission
/ Pregnancy Complications, Infectious - virology
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Vasculitis, Central Nervous System - virology
/ Viremia
/ Virology
